Privacy-Preserving Data Dissemination in Engineering and Computer Science
Explore the proposed methods for privacy-preserving data dissemination in UT Dallas' Erik Jonsson School of Engineering & Computer Science, involving perturbed datasets, significant SNPs, noise addition, and privacy preservation techniques.
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UT DALLAS Erik Jonsson School of Engineering & Computer Science Privacy Preserving Data Dissemination Dr. Murat Kantarcioglu (muratk@utdallas.edu) Harichandan Roy (harichandan.roy@utdallas.edu) Data Security and Privacy Lab UT Dallas FEARLESS engineering
What is Task 1? Given- case/control datasets Desired result- perturbed datasets Method applied snps snps Case Control Perturbed snps Desired Result anonymous FEARLESS engineering
Proposed Method: NCBI Added Noise Main Idea: Keep the significant SNPs MAFs, add noise to non-significant SNPs MAFs For significant snips Define significant and non-significant snips based on p-value using pLink (significant if p is less than 0.05) Keep MAF as it is in case FEARLESS engineering
Proposed Method: NCBI Added Noise For non-significant snips Take variance of MAF in case Get gaussian random values, noises, with mean = 0 and std = (a*Math.sqrt(var)), where a = 3. Finally, add noise to NCBI MAF If NCBI MAF does not exist, add noise to average MAF of case and control Order all perturbed MAFs as in case file FEARLESS engineering
Flow Diagram FEARLESS engineering
Results For chr2, Used NCBI Added Noise Method Got power 8 <20 For chr10, Used Average Case/Control Method Got power 8 <20 Power 8 <20 It means desired level of privacy is preserved Results are not always same FEARLESS engineering
Other Tries Method Applied Control-maf for non-sig Avg-maf for non-sig NCBI-maf for non-sig Control-maf/2 for non-sig Avg-maf/2 for non-sig NCBI-maf/2 for non-sig Min-maf for sig. Max-maf for sig Gaussian noise for non-sig Result for chr2 Power > 60 Power > 60 Power > 40 Power < 5 Power < 5 Power < 5 Power > 40 Power > 40 Power < 15 Result for chr10 Power < 10 Power < 10 Power < 10 Power > 20 Power > 30 Power > 10 Power < 10 Power < 10 Power <10 FEARLESS engineering
Questions? FEARLESS engineering
