Production and Separation Protocol for 111Ag Radiopharmaceuticals
Explore the steps involved in the development of a separation and recycling protocol for 111Ag production at Laboratori Nazionali di Legnaro. Discover the up-to-date protocol, possible improvements, and key conclusions from the ISOLPHARM project. Dive into the production of 111Ag via neutron activation, radiopharmaceutical design, synthesis, radiolabeling, and testing for in-vitro and in-vivo applications.
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Presentation Transcript
Laboratori Nazionali di Legnaro INFN ISOLPHARM 111Ag Production and Separation at L.E.N.A Steps for the development of a separation and recycling protocol G. Grosso March 15th, 2024 1
Outline I. Up-to-date protocol II. Possible improvements III. Conclusions 2
Possible improvements Ag polish on TK200 Procedure 1. 2. Precondition 2 mL TK200 cartridges with 5 mL 0.5M HCl Load Ag fraction obtained on the LN Resin cartridge through the TK200 cartridge => Ag will remain retained. Rinse cartridge with 5 mL HCl 0.5M=> this will remove last traces of Cu => waste Elute Ag with 6 mL water. 3. 4. Recovery Ag: 80% in 6 ml 4
Conclusions To move beyond the main objectives of the ISOLPHARM project and studies and interest in 111Ag- based radiopharmaceuticals, the first batches nuclide were carried out at LENA to promote of this 1. Production of 111Ag via neutron activation Development of a separation and recycling protocol Radiopharmaceutical design and synthesis Radiolabeling Testing in-vitro labeled compound 2. 3. 4. 5. and in-vivo
