Return of the Old Library - Recommendations and Considerations
In this project, the committee members aim to restore the old library, increase collaborations with university departments, and preserve Gondourian heritage. The methodology includes aligning with the university's vision, environmental scanning, and user-driven design. The recommendations focus on the library's special emphasis on Gondourian history, culture, art, and architecture.
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Long-term disability progression T2 and T1 lesion volume Whole brain / GM volume changes Cortical lesion volume / number Measures obtained using other advanced imaging techniques (MTI, MR spectroscopy)? needs confirmation in large studies Disability Inflammation From RIS to first relapse Younger age Male sex Spinal cord lesions Degeneration SPMS Time RIS CIS CDMS Short-term disability progression Early relapse frequency Inter-relapse interval T2 lesion volume / number From CIS to CDMS T2 lesion volume / number GdE lesion number Presence of cortical lesions
EDSS Early relapses and late disease evolution 7 6 Late disease evolution not influenced by focal inflammation Time from EDSS 3/4 to EDSS 6/7 not affected by early relapses 5 4 3 Confavreux et al. 2003 Lyon database 2 Scalfari et al. 2010 London Ontario database 1 Rennes database Leray et al. 2010 Time (years)
Stimulate standardisation of imaging reports & development of software 33 Improve image acquisition & analysis techniques for measuring lesion load and brain atrophy, especially for within-patient follow-up 30 Stimulate studies aiming at characterising brain recovery mechanisms in MS in order to generate novel hypotheses for potential targets or modes of intervention 19 Stimulate studies aiming to correlate MRI outcomes with clinical outcomes 18 0 10 20 30 40 Distribution of priorities among attendants (%)
Evaluate appropriateness of Tx at individual patient level 22 Evaluate whether combination Tx of DMDs with different MOAs can enhance reponse (while still being safe) 19 Reach consensus on clear definitions of clinically relevant Tx response 19 Validate correlation between biomarkers and Tx response/AEs 18 Validate association between biomarkers and risk of disability progression 15 Further explore and validate patient preference profiles 6 Further validate the readout of OCT for studying within-patient changes of neurodegeneration 2 0 5 10 15 20 25 Distribution of priorities among attendants (%)
Bone marrow Escalation therapy Induction therapy transplantation? Mitoxantrone Alemtuzumab (Ocrelizumab) NTZ (JCV- or low idx) Alemtuzumab (JCV+ or high idx) Fingolimod (combinations?) - Daclizumab Mild-moderate: Teriflunomide - DMF - (Laquinimod) IFN (pegylated?) or GA (40 mg tiw?) Severe: NTZ (JCV- or low idx) - Fingolimod (JCV+ or high idx)
0.3 0.27 0.25 0.23 Relative importance 0.2 0.2 0.18 0.15 0.12 0.1 0.05 0 Years to progression PML Liver failure Leukaemia Relapse Treatment attribute
