Selecting a Software System for Clinical Trials Management at Lupus Center
This information provides insights into selecting a software system for managing clinical trials, specifically at the Lupus Center. It covers details about lupus, common myths, the Lupus Center at the University of Pittsburgh, clinical trials, and an alternative software system called CTMA for clinical trials management.
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Task 4.3 Task 4.3 Identification Identificationof of spatio spatio- -temporally temporallyclustered clusteredlesions lesions( (CL CL) ) Double Strand Breaks (DSBs), preferentially repaired by Homologous Recombination (HR) pathways in respect of Non-Homologous End Joining (NHEJ). Non-double or Single Strand Breaks (SSBs), mainly restored by Base Excision repair (BER) and Nucleotide Excision repair (NER).
Task 4.3 Task 4.3 Identification Identification of of spatio spatio- -temporally temporally clustered clustered lesions lesions (CL) (CL) Western blotting data overview Istituto di Bioimmagini e Fisiologia Molecolare (IBFM) - CNR - SS Cefal 19/04/2025
Task 4.3 Task 4.3 Estimation Estimation of of Reactive Reactive Oxygen Oxygen Species Species (ROS) generation (ROS) generation After cell irradiation, it can be described a time-dependent decrease of radical species (e.g. the hydroxyl radical OH) in favor of molecular products (Oxidized nucleic acids, proteins and lipids). nano sec.- minutes hours hours-days Irradiated cells were incubed with 2 ,7 -Dichlorofluorescin diacetate (DCFH-DA), a cell-permeable non- fluorescent molecule. Then, it will be de-esterified intracellularly turning to the highly fluorescent 2 ,7 - dichlorofluorescein upon oxidation. Applications include sensitive and rapid quantitation of oxygen-reactive species in response to oxidative stress.
Task 4.3 Task 4.3 Estimation Estimation of of Reactive Reactive Oxygen Oxygen Species Species (ROS) generation (ROS) generation Panc-1 cells were irradiated in October 2019 with the doses of 1,2 and 5 Gy at the mid-SOBP and distal position Istituto di Bioimmagini e Fisiologia Molecolare (IBFM) - CNR - SS Cefal 19/04/2025
