Sensitivity Analysis of Metformin in Pregnancy Interventions

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Conducting a leave-one-out sensitivity analysis to compare the effects of Metformin on various pregnancy outcomes against all interventions, including gestational weight gain, pre-eclampsia, pregnancy-induced hypertension, preterm birth, gestational age at delivery, C-section rates, and development of gestational diabetes mellitus.

  • Sensitivity analysis
  • Metformin
  • Pregnancy interventions
  • Pregnancy outcomes
  • Gestational diabetes

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  1. Supplementary Fig. S4: Sensitivity analysis: Leave-one-out a) Gestational weight gain: Metformin vs. all interventions b) Pre-eclampsia: Metformin vs. all interventions

  2. Supplementary S4 Fig: Sensitivity analysis: Leave-one-out (continued) c) Pregnancy-induced hypertension: Metformin vs. all interventions d) Preterm (all causes): Metformin vs. all interventions

  3. Supplementary S2 Fig: Sensitivity analysis: Leave-one-out (continued) e) Gestational age at delivery: Metformin vs. all interventions f) C-section rates: Metformin vs. all interventions

  4. Supplementary S4 Fig: Sensitivity analysis: Leave-one-out (continued) g) Development of GDM: Metformin vs. all interventions Sensitivity analysis of outcome measures one study was removed. C-section=ceserean-section; GDM=gestational diabetes mellitus; met=metformin. Odds Ratio or mean difference (where appropriate) 95% CI. Fixed or random-effect models where appropriate.

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