Serum Creatinine and Creatinine Clearance
Serum creatinine and creatinine clearance tests are essential in assessing kidney function by measuring waste product levels in blood and urine. Learn about creatinine, its relation to muscle mass, kidney function, reference values, and conditions affecting levels. Discover medications that can impact blood creatinine levels.
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Presentation Transcript
Serum Creatinine Presented By Assist.Lecturer Sarah Sameer Sami M.Sc. In Biochemistry/ Clinical laboratory sciences
What is creatinine and creatinine clearance test? This test measures the level of the waste product creatinine in blood and urine This test provides more sensitive measure of renal damage than blood urea? What is creatinine? It is a non protein end product of creatine metabolism Its amount in serum is proportional to muscle mass
It is easily excreted by kidneys with minimum or no tubular reabsorption It is directly related to GFR Its level remains normally constant Blood creatinine level: It shows how well the kidneys are working It is higher in men than in women
Creatinine clearance test: It measures how well creatinine is removed from the body by kidneys It gives better information than blood creatinine test on how well the kidneys are working It is done on both a blood or urine sample
Reference values: Serum Men: 0.7-1.2 mg/dl Women: 0.5-0.9 mg/dl Clearance test Men: 97-137 ml/min Women: 88-128 ml/min
Pathological: Increase: Increased rate of formation:
Decrease: Muscle disease such as muscle dystrophy
What are medicines that increase blood creatinine? Anti hypertensives: ACE inhibitors ex: captopril NSAIDs: ibuprofen, naproxen Diuretics: furosemide Antibiotics: aminoglycosides (gentamicin) and cephalosporins (cefoxitin)
