Structured Approach to Comatose Patient Assessment and Management

Structured Approach to Comatose Patient Assessment and Management
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Developing a structured approach to assess and manage comatose patients is crucial in emergency settings. This involves initial steps such as ensuring safety and adequate resources, followed by assessing airway, breathing, and circulation. Generating a list of potential differentials aids in narrowing down the diagnosis, focusing on intracranial and extracranial causes. Each category requires specific considerations, including surgical sieves for intracranial causes and metabolic factors for extracranial causes.

  • Comatose Patient
  • Emergency Medicine
  • Patient Assessment
  • Management
  • Differential Diagnosis

Uploaded on Mar 07, 2025 | 0 Views


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  1. Approach to the comatose patient Stephen Lo

  2. Introduction Focus on developing a structured approach to coma Can be also applied to exam questions

  3. Case 50 year old polynesian lady presented with headache followed by LOC How would you assess and manage this patient?

  4. Investigations

  5. My approach Initial management Differential diagnosis Investigations Management

  6. Initial steps: safety + ensure adequate resources Ask for resources ABC, basic resuscitation

  7. Assessment of airway, breathing, and circulation Airway patency Airway protection: What is the GCS Is there protective reflexes present What is the risk of aspiration Are there secretions Rate and pattern of ventilation Circulation: signs of shock, hypotension. Consider maintaining CPP. In this case, I would put Blood sugar levels at the priority of the ABCs

  8. Differential diagnosis Need to construct a list of differential diagnosis at this point.

  9. Approach to the diagnosis Need a simple way of classifying causes Intracranial Extracranial

  10. Intracranial Consider surgical sieve or other pneumonics Need to include the key ones such as: bleed, stroke, infection, trauma, Seizures, rarer causes such as tumours, autoimmune, vasculitis, PRES context specific differentials such as vasospasm, hydocephalus in SAH

  11. Extracranial These are generally metabolic in nature. Again, have a sieve that you are familiar with, but need to include the most common ones including: Drugs: direct effect, indirect effects Acid base Hypoxia/hypercarbic Temperature Organ function: Kidney and liver Nutritional Electrolyte disturbance Endocrine Sepsis

  12. Mimics of coma Severe peripheral neuropathy Guillain Barre syndrome Botulism Critical illness neuropathy Locked in syndrome Akinetic mutism

  13. Assessment History and examination to rule out or in your differentials Catagorize into three broad categories based on patient s signs Coma with focal signs: Suggests an intracranial event Coma with meningism: Suggests meningitis, SAH Coma without signs: Suggests a very diffuse intracranial lesion or an extracranial cause

  14. Investigations Consider all your options Systemic investigations CT head Lumbar puncture: MCS, PCR, antibodies CT angiogram EEG MRI SSEPs Cerebral angiogram

  15. Whats your management now? Medical management Specific management Position of patient, CO2 control, BP control, Osmotherapy, sedation, sugar, seizure control, temperature General management Interventions Radiological interventions Surgical management

  16. Case 2 49 yo male thai chef that was found collapsed at home, brought in by ambulance. How would you manage this patient?

  17. Assessment ABC: Noisy breathing GCS: E1V2M5 Sats: 84 % on 6L BP 190/80, HR 90/min

  18. Further clinical assessment Right side movement less than left Pupils equal and reactive

  19. Investigations

  20. Finding underlying causes Thromboembolic Consider source of clot Bleeding Is there an underlying abnormality Infection Are there underlying structural abnormality or immunosuppression Epilepsy Adult onset always need to consider cause

  21. Further investigations ASD on echo Paradoxical embolus and therefore infarct

  22. Other learning points That an extensive unilateral lesion can also cause reduced LOC

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