Uncouplers and Inhibitors of Oxidative Phosphorylation: Types and Effects
Learn about uncouplers and inhibitors of oxidative phosphorylation, substances that disrupt the coupling of oxidation and phosphorylation within mitochondria, leading to decreased ATP synthesis. Discover different types such as oligomycin and 2,4-dinitrophenol, along with physiological uncouplers like thermogenin and Thyroxin. References to biochemistry textbooks are provided for further reading.
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Presentation Transcript
Uncouplers / Inhibitors of oxidative phosphorylation Pratima Katiyar Date: 6/5/22 time 2-3 pm
Definition Abolish the coupling between oxidation and phosphorylation through increase the permeability of innermitochondrial membrane and stop the ATP synthesis.
types Inhibitors: oligomycin bind to F0-F1 subunit and enzyme ATPase. Suppress oxygen consumption and less ATP formation. Synthetic uncouplers: 2,4 dinitrophenol is proton ionophore which uncouple phosphorylation. Physiological uncouplers: thermogenin, UCP-1, bilerubin, FFA, Thyroxin, estrogen etc
References Harpers Biochemistry by Robert K. Murry, DarylK. Biochemistry by D. Sataynarayan Textbook of biochemistry by Lal and Pandey
