Understanding Cardiac Effects of Toxic Substances
Explore the impact of toxic substances on myocardial cell action potential, focusing on the ECG changes induced by drugs like TCAs, chloroquine, antipsychotics, and more. Learn from Clinical Toxicologist Geoff Isbister about the key markers to look for in toxicology cases.
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Presentation Transcript
ECG IN TOXICOLOGY: What are we looking for? Geoff Isbister Clinical Toxicologist Calvary Mater Newcastle
MYOCARDIALCELLACTIONPOTENTIAL ECG 1 +20mV 2 3 0 4 -90mV IC EC Na + ATPase K+ K+ K+ Ca + + Na + K + Quinidine like drugs (TCAs, chloroquine, antipsychotics, antiarrhythmics, antihistamines, etc) block Na+ & K+ channels
MYOCARDIALCELLACTIONPOTENTIAL ECG 1 +20mV 2 3 0 4 -90mV IC EC Na + ATPase K+ K+ K+ Ca + + Na + K + Quinidine like drugs (TCAs, chloroquine, antipsychotics, antiarrhythmics, antihistamines, etc) block Na+ & K+ channels
MYOCARDIALCELLACTIONPOTENTIAL ECG 1 +20mV 2 3 0 4 -90mV IC EC Na + ATPase K+ K+ K+ Ca + + Na + K +
