Understanding Evidence-Based Medicine with Jeremy Howick
Explore the principles of Evidence-Based Medicine (EBM) through the insights of Jeremy Howick from the Centre for Evidence-Based Medicine. Learn about hierarchies, mechanisms, effect sizes, and more to enhance your understanding of scientific evidence.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
You are allowed to download the files provided on this website for personal or commercial use, subject to the condition that they are used lawfully. All files are the property of their respective owners.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.
E N D
Presentation Transcript
Jeremy Howick Centre for Evidence-Based Medicine
1. There are no hierarchies 2. EBM has always recognized mechanisms 5. The best way to improve evidence would be to have a minimum effect size requirement 3. Philosophers of science have ignored problems with the evidential role of mechanisms 4. The fact that mechanistically sound hypotheses are more believable is irrelevant.
1. There are no hierarchies: GRADE Step 1: Initial ranking Step 2: upgrade/downgrad e Step 3: assign final grade Downgrade for: - Inconsistency - Indirectness - Imprecision - Publication bias Upgrade for: - Large consistent effect - Dose response - Confounders only reducing size of effect RT: High OS: low HIGH MODERATE LOW VERY LOW
1. There are no hierarchies: OCEBM PICK A BOX! Cohort Study randomized trial Case Series Mechanistic reasoning systematic review
2. EBM has always recognized a role for mechanisms
3. Proponents of mechanisms have ignore problems with mechanisms
1. There are no hierarchies 2. EBM has always recognized mechanisms 5. The best way to improve evidence would be to have a minimum effect size requirement 3. Philosophers of science have ignored problems with the evidential role of mechanisms 4. The fact that mechanistically sound hypotheses are more believable is irrelevant.
Thanks again! jeremy.howick@phc.ox.ac.uk
