Understanding Sarcoidosis: Overview, Symptoms, Diagnosis, and Treatment
Explore the comprehensive guide on Sarcoidosis, a multisystem inflammatory disease, covering its history, immunological findings, epidemiology, genetics, etiology, pathogenesis, clinical manifestations, diagnosis, and treatment options. Learn about the genetic predisposition, immune responses, and treatment approaches for this condition affecting various organs.
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Presentation Transcript
Sarcoidosis Sarcoidosis Robles D az Efr n
HISTORIA Quien acu el t rmino sarkoid (por su semejanza a lesiones sarcomatosas) 1898 enfermedad, J. Hutchinson J. Schaumann Describi por primera vez, bajo el nombre de psoriasis papilar en 1877 al reunir entre 1914 y 1924 todas las localizaciones del proceso, bajo el nombre de linfogranulomatosis benigna Describe el car cter multisist mico a la C. Boeck (1998-1877)
Se presenta Hallazgos Que es? con: Inmunol gicos Depresi n de la inmunidad celular y Infiltraci n pulmonar, lesiones cut neas y respuesta inmune de Th1 en los sitios La Sarcoidosis es una enfermedad multisist mica. oculares. donde se localiza la Enfermedad.
Epidemiologa y gentica La predisposici n a adquirir Sarcoidosis parece gen ticamente determinada, sin embargo solo un peque o grupo de alelos de HLA han sido posibles de identificar asociados a la susceptibilidad de la enfermedad, tanto de clase I (HLA B7, HLA B8), como de clase II (HLA-DR3, DR5, DR6, DR8, DR9, DR14, DR15 y DR17)[9].
Etiologa C lulas T y macr fagos Factores quimiot cticos y citoquinas Aire inspirado Alveolitis linfoc tica Respuesta inflamatoria Granuloma Las c lulas T activadas
