Understanding Urea: Functions, Measurement, and Clinical Significance
Learn about urea, its role in the body, how it is measured for renal function assessment, and the various factors influencing urea levels. Explore the enzymatic and colorimetric methods used for urea measurement. Discover the significance of urea levels in different health conditions.
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Presentation Transcript
More than 90% of urea is excreted through the kidneys in urines. Measurement of the plasma or serum urea concentration is widely regarded as a test of renal function. However, a number of nonrenal factors also influence the circulation Urea concentration, urea increased level occurs when proteins catabolism is accelerated, burns, stress, myocardial infarction... Urea is decreased in acute liver destruction and is accompanied with increased ammonium level. Urea level is generally studied in conjunction with creatinine level (urea/creatinine ratio) to refine post-renal or pre-renal diagnosis
Principle Enzymatic and colorimetric method based on the specific action of urease which hydrolyses urea in ammonium ions and carbon dioxide. Ammonium ions then form with chloride and salicylate a blue-green complex. This coloration, proportional to urea concentration in the specimen, is measured at 600 nm.
