Uric Acid: Formation, Effects, and Testing
Uric acid is the end product of purine metabolism, formed both endogenously and exogenously. High levels can lead to gout, kidney stones, and other health issues. The uric acid test helps diagnose gout, monitor treatments, and assess certain conditions. Reference values and factors influencing uric acid levels, both high and low, are outlined. Learn more about the role of uric acid in the body and its implications through this informative guide.
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Presentation Transcript
Uric Acid Presented By Assist.Lecturer Aseel Ghassan Daoud M.Sc. In pharmacy/ Clinical laboratory sciences
What is uric acid? It is the end product of metabolism of purines which are present in nucleic acids of nucleoproteins It is formed endogenously exogenously from from nucleoproteins metabolism of purines taken in food and
It is formed in liver and filtered by kidneys to be excreted in urine with little amount passes in stool. High uric acid levels in blood occur when its formation is too much or its excretion is low
What can high uric acid level in blood lead to? It will form solid crystals within joints which is painful and called gout if remain untreated it will lead to hard lumpy deposits called tophi It can also cause kidney stones or kidney failure
Why is uric acid test done? Help diagnose gout Check for kidney stones Check if medicines are working Check for uric acid level in patients on chemotherapy or radiation
Reference values: Child : 2 - 5.5 mg/dl Men : 3.5 - 7.2 mg/dl Women : 2.6 - 6 mg/dl
High values: Individual differences Kidney disease Cancers (leukemia, lymphoma, multiple myeloma) or its treatments Hemolytic anemia, sickle cell anemia, heart failure Alcohol dependence, preeclampsia, obesity
Starvation, malnutrition, lead poisoning Lesch-Nyhan syndrome Medicines (diuretics, vit.c, niacin, warfarin) Foods
Low values: Sever liver disease, Wilson s disease Syndrome of inappropriate ADH Diet low in proteins Large dose of aspirin, allopurinol
