Vitamin B12 Deficiency: Causes, Symptoms, and Treatment Options
Explore the importance of Vitamin B12 in the body, potential deficiency symptoms, treatment options, and relevant research findings. Learn more about Vitamin B12 through informative slides and reputable sources provided in this comprehensive content.
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B12? B12 o B12 - , , o B12 12 , , ; <1% B12 , 2 B12 NIH. http://ods.od.nih.gov/factsheets/VitaminB12/. 16 2019 . 19http://www.merckmanuals.com/home/disorders-of-nutrition/vitamins/vitamin-b-12 16 2019 .
: - II . II-R LRP-2 N5 - THF Me- Me- - II -Me -Me MS MTHFR - THF S- (SAM), 100 , , , , . - - -Ad -Ad Ad- Ad- MCM - - L- - - - - : , . 3Langan RC et al. Am Fam Physician 2011;83:1425 1Dali-Youcef N et al. QJ Med. 2009;102:17 2 B12 NIH. http://ods.od.nih.gov/factsheets/VitaminB12/. 16 2019 . Quarterly Journal of Medicine
B12? B12 : , , .) ( , ). , . 3Langan RC et al. Am Fam Physician 2011;83:1425 1Dali-Youcef N et al. QJ Med. 2009;102:17 2 B12 NIH. http://ods.od.nih.gov/factsheets/VitaminB12/. 16 2019 . Zeisel S.H. Epigenetic mechanisms for nutrition determinants of later health outcomes // Am. J. Clin. Nutr. 2009. Vol. 89(5). P. 1488 1493 A. Miller et al. / Journal of the Neurological Sciences, 2005 Jun 15;233(1-2):93-7. Quarterly Journal of Medicine
B12: ? , B12 B12 ~ 170-250 / (120-180 / ) , , , B12 B12. 50% 12 B12 , B12, B12, ( ) ( ) . . - II II-R LRP-2 N5 - THF -Me - II Me- Me- -Me MS MTHFR - THF - - Ad- Ad- -Ad -Ad MCM - - A. Miller et al. / Journal of the Neurological Sciences, 2005 Jun 15;233(1-2):93-7 1Dali-Youcef N et al. QJ Med. 2009;102:17 2 B12 NIH. http://ods.od.nih.gov/factsheets/VitaminB12/. 16 2019 . Quarterly Journal of Medicine
B12 , ( , , ) II H2- 3Langan RC et al. Am Fam Physician 2011;83:1425
B12 - ( ) - ( ) - B12, , ( , ) ( ) 3Langan RC et al. Am Fam Physician 2011;83:1425 15Devalia, Hamiton and Molloy British Journal of Haematology, 2014, 166, 496 513
B12 20% B12 . 70-90% 10-30% - - 12 - Me -B12 T A -B12 MM B12, B12, Nexo E et al. AM J Clin Nutr.2011.10.3945/ajcn.111.013458 Herrmann W et al. Dtsch Arztebl Int 2008; 105: 680 5 Put science on your side. . . 10
B12 B12 80% 75% 70% 60% 60% 50% 40% 30% 22% 20% 12% 10% 0% (n=50) / (n=114) (n=228) (n=109) 4Obeid R, et al Clin Chem 2002;48:2064-5 5Herrmann W et al Clin Chem Lab Med 2003;41: 1478-88 6Herrmann W et al Am J Clin Nutr 2003;78:131-67 7Lloyd-Wright Z et al., Clin Chem., 2003; 49: 2076-8. 8Miller JW et al., Clin Chem 2006; 52: 278-85 9Valente et al Clin Chem 2011 % X - -
B12 B12 B12 ( 45% *) ( ) ( / / ) B12 B12 B12 (14%*) , , Valente et al Clin Chem 2011
12 Active-B12 results by vitamin B12 concentration 400 A = B12 B C = B12 B12 Ranges A: 0 150 pmol/l [Active-B12] pmol/L 300 B: 150 300 pmol/l 12 B12 . C: > 301 pmol/l 200 151-300 pmol/L B12, , B12 . 100 35 0 A B C B12 ranges B12 cut-off 156 pmol/L Active-B12 cut-off 35 pmol/L Raw Data provided by Prof. W Herrmann, Zentrallabor der Universit tskliniken des Saarlandes, Homburg, Germany Put science on your side. 13
B12 () - Valente . 1 0,9 B12 ROC-AUC* 0,90 0,8 ( ) 0,7 B12 ROC-AUC 0,80 0,6 0,5 - 0,4 ( / ) ( / ) MM ( / ) 0,3 0,2 0,1 0 0 0,2 0,4 0,6 0,8 1 1- ( ) * ROC-AUC , .1 ROC- , MMA B12, <33 / . - 699; B12 - 67. AUC (0,90) (P 0,0002) (0,80), MMA(0,78) 9Edward Valente, John M. Scott, Per-Magne Ueland, Conal Cunningham, Miriam Casey, Anne M. Molloy Diagnostic Accuracy of Holotranscobalamin, Methylmalonic Acid, Serum Cobalamin, and Other Indicators of Tissue Vitamin B12 Status in the Elderly Clinical Chemistry Jun 2011, 57 (6) 856-863; DOI: 10.1373/clinchem.2010.158154
B12 12 , B12 , B12 , Devalia, Hamiton and Molloy British Journal of Haematology, 2014, 166, 496 513 http://onlinelibrary.wiley.com/doi/10.111/bjh.12959/pdff http://www.bcshguidelines.com/4 HAEMATOLOGY GUIDELINES.html 16 2019 .
B12 B12 B12 ( ) 35 / B12 ( ) < 35 / * * . , , , B12 , . 16 Clinical guide, Prof. Herrman, Germany
B12 B12 B12 B12 150-250 / B12 < 150 / B12 > 250 / , 12 12 18 Schneede J., Scan J Clin Lab Invest 2003; 63: 369 - 376
- B12 ( )? ? ? B12, B12 B12 , / GPC MMK 12 ( B12 - 12 , B12 - 9 - 10 ) - Cobasorb ? ? <35 / B12 ( . BCSH ) 15Devalia, Hamiton and Molloy British Journal of Haematology,2014,166,496 513 18 17https://www.nice.org.uk/advice/mib40
(BCSH) (NICE Medtech) (1) BCSH: Devalia, Hamiton Molloy http://onlinelibrary.wiley.com/doi/10.1111/bjh.12959/pdf http://www.bcshguidelines.com/4_HAEMATOLOGY_GUIDELINES.html 166, 496 513 (2) NICE Medtech British Journal of Haematology, 2014: https://www.nice.org.uk/advic/mib40
