Evaluation of Genomic Content in Case R
This evaluation focuses on the genomic content in Case R, involving a 4-year-old female with short stature and her mother with a similar condition. The assessment includes the genes involved, overlap with established regions, gene number evaluation, and detailed examination of the genomic content, specifically regarding the 7q11.23 region. Various scoring metrics and evidence types are utilized to provide a comprehensive analysis.
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Presentation Transcript
3GPP TSG-RAN WG4 Meeting #94-e-bis Electronic meeting, 20 30 April 2020 DRAFT_R4-2005220 WF on new intra WF on new intra- -band BW classes classes band BW Ericsson
Background According to the WID [1], wideband operations in multiples of 20 MHz should be supported by both multiple serving cells (i.e. CA of 20 MHz cells) and one serving cell with bandwidth > 20 MHz with potential scheduling constraint (i.e. wideband carrier ). The RAN1 objectives in the WID state Physical layer aspects including [RAN1]: [ ] Wide band operation (in integer multiples of 20MHz) for DL and UL for NR-U supported with multiple serving cells, and wideband operation (in integer multiples of 20MHz) for DL and UL for NR-U supported with one serving cell with bandwidth > 20MHz with potential scheduling constraint subject to input from RAN2 and RAN4 on feasibility of operating the wideband carrier when LBT is unsuccessful in one or more LBT subbands within the wideband carrier. For all wide-band operation cases, CCA is performed in units of 20MHz (at least for 5GHz). RAN4 should therefore specify NR CA BW classes supporting both modes of wide band operation in multiples of 20 MHz Wide band operation (in integer multiples of 20MHz) for DL and UL for NR-U supported with multiple serving cells not possible with current CA BW Classes 1. RP-191575
Way forward Define three new NR CA bandwidth classes to allow intra-band contiguous CA in for NR- UBand n46 in multiples of 20 MHz and wider bandwidths class M : 50 MHz BWChannel_CA 1820 MHz, number of contiguous CC = 3 The lower limit also covers one 10 MHz channel bandwidth (10 + 20 + 20 MHz to cover 50 MHz allocation) class N : 80 MHz BWChannel_CA 240160 MHz, number of contiguous CC = 4 class O : 100 MHz BWChannel_CA 3200 MHz, number of contiguous CC = 5 belonging to the same fall-back group Upper limits defined as multiples of the 640 MHz channel bandwidth smaller total aggregated bandwidth, reduces the need for BCS larger aggregated bandwidths covered by existing classes (see next slide) 2 CC covered by the existing CA BW class B and C The classes M, N and O only applies to NR-UBand n46 operation Note 1: agreed assumptions on number of CCs for DL/UL and scope (e.g. two contiguous CCs in the UL) for Rel-16 remains Note 2: the channel raster frequencies for the 10 MHz are restricted
Relation to other BW classes Larger aggregated bandwidths for intra-band contiguous CA will could be covered by the existing CA BW classes and larger carrier bandwidths, e.g. 3 * 80 MHz by BW Class D (although difficult in the 5470-5725 MHz due to emissions requirements) 4 * 80 MHz by BW Class E (not possible in the 5 GHz band) 3 * 60 MHz is not possible in the 5 GHz band with agreed channel raster (but 20 MHz + 2 * 80 MHz would be) 2 * 60 MHz is covered by BW Class D (could also be configured as 80 MHz + 40 MHz) and with the fallback paths covered by the existing specification Most of the wider aggregated bandwidths above would not be supported in n46 subject to the agreed channel raster, but could be used in the 6 GHz range This suggests that the new classes should cover aggregation of 10 MHz, and 20 MHz, and 40 MHz and 60 MHz bandwidths that is not fully covered by the existing classes implies a smaller aggregated channel bandwidth for these BW classes, which reduces the need for specification of BCS with smaller aggregated bandwidths for a given class combinations of 40 MHz carriers only could be covered by the existing B, G and H for up to 4 CCs, but the combination 5 * 40 MHz would not Therefore, n * 640 MHz chosen as the upper limits of M, N and O, the combinations up to 54 * 640 MHz providing a fallback path to a single 640 MHz carrier
