MESA Operations Subcommittee Meeting Report and Analysis
Explore the detailed report and analysis from the MESA Operations Subcommittee meeting, covering follow-up calls, participant communications, exam outcomes, and retention rates. Gain insights on completion rates by site and ethnicity. Get a comprehensive overview of the meeting discussions and outcomes.
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MESA Operations Subcommittee Meeting
Operations Subcommittee Report 1. Follow-up calls 2. Participant Communications 3. Exam 6
Follow-up Call Retention 100% 85% 80% 60% Done 40% 20% 0% FU1 FU2 FU3 FU4 FU5 FU6 FU7 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 Retention = Completed / (Enrolled Dead)
Follow-up Retention by Ethnicity All Sites 100 90 85% 80 Retention Rate White 70 A-A Hisp. Chin. 60 50 40 FU7 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 Retention = Completed / (Enrolled Dead) except FU 15 (windowed)
Follow-up 14 Completion by Site Contact not made Follow- up Due Interviews Completed Not Site Name Contacts Made Completed Wake Forest Columbia Hopkins Minnesota NWU UCLA Total 907 875 96% 788 87% 87 32 956 938 933 1028 1153 5915 900 793 892 960 1033 5453 94% 85% 96% 93% 90% 92% 800 747 789 902 889 4915 84% 80% 85% 88% 77% 83% 100 46 103 58 144 538 56 145 41 68 120 462
Follow-up 15 Completion by Site Follow- up Due 620 643 557 637 686 735 3878 Interviews Completed 411 565 524 562 655 623 3340 Not Contact not made 177 41 10 33 0 1 262 Site Name Contacts Made Completed 32 37 23 42 31 111 276 Wake Forest Columbia Hopkins Minnesota NWU UCLA Total 443 602 547 604 686 734 3616 71% 94% 98% 95% 100% 100% 93% 66% 88% 94% 88% 95% 85% 86%
Follow-up Retention by Site WFU Columbia JHU 100 100 100 90 90 90 85% 80 80 80 70 70 70 60 60 60 50 50 50 40 40 40 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 NWU UCLA Minnesota 100 100 100 90 90 90 85% 80 80 80 70 70 70 60 60 60 50 50 50 40 40 40 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 FU8 FU9 FU10 FU11 FU12 FU13 FU14 FU15 Retention = Completed / (Enrolled Dead) except FU 14 and 15 (windowed)
Follow-up 16 Completion by Site Follow- up 16 Due Interviews Completed Not Contact not made Site Name Contacts Made Completed Wake Forest Columbia Hopkins Minnesota NWU UCLA Total 140 53 38% 51 36% 2 87 146 134 148 155 177 900 93 127 106 152 164 695 64% 95% 72% 98% 93% 77% 89 123 103 145 147 658 61% 92% 70% 94% 83% 73% 4 4 3 7 53 7 42 3 13 205 17 37
Follow-up Retention F/U 14 finished in October 2014 Included Medications Inventory and Residential History Review F/U 15 will end in June 2015 (70% done) No Medications Inventory or Residential History Review FU 16 started October 2015 (16% done) Includes Medications Inventory, new questions for gout, food security, e-cigarette use, blood thinner/anticoagulant use
Contacts and Proxies We have multiple contacts per participant currently Proposal: Ask participant to name a proxy who could provide health data for them Contact the proxy to let them know about MESA, etc Obtain a signed letter from the participant for future use
Newsletter Will mail in early March Next newsletter planned for June 2016
Exam 6 Core Exam #Participants Time Burden ~ 4000 PPTs. Average duration: 125 minutes Consent/Check-in Seated blood pressure Anthropometry Phlebotomy Medical history Personal history/demographics Medication Inventory Exam components
Exam 6 Ancillary Studies (<13th %) PI Title Transition from risk factors to early HF: prevalence, pathogenesis,and phenomics Atrial fibrillation burden, vascular disease of the brain MRI in MESA Pulmonary microvascular perfusion in the Multi-Ethnic Study of Atherosclerosis Obesity-related epigenetic changes and type- 2 diabetes Bertoni, Alain Heckbert, Susan Barr, Graham Liu, Yongmei
Exam 6 Ancillary Studies Bertoni, Alain Transition from risk factors to early HF: prevalence, pathogenesis,and phenomics All participants at Exam 6 (~4000) 300 for exercise testing at 1 site 90 Minutes for all 2 hours for exercise testing subset Echocardiography, six minute walk test, physical activity questionnaire, heart failure symptoms survey #Participants Time Burden Exam components Three sites: Arterial tonometry One site: CPET
Exam 6 Ancillary Studies Heckbert, Susan Atrial fibrillation burden, vascular disease of the brain MRI in MESA #Participants 1500 ppts at all sites (~250/site) 1/3 afib, 1/3 high risk, 1/3 controls Time Burden Exam 6: 50 minutes F/U Exam (1-2 years later): 65 minutes Exam components Exam 6: Cognitive function testing, application of ECG patch monitor, physical functioning questionnaire, 5 ml blood. (wear one ECG monitor for 14 days, return it, self-apply a second ECG monitor for 14 days). F/U Exam: Brain MRI and second physical functioning test on 1350 (of above 1500 ppts)
Exam 6 Ancillary Studies Barr, Graham Pulmonary microvascular perfusion in the Multi-Ethnic Study of Atherosclerosis #Participants 2000 participants selected from MESA Lung II Time Burden Consent, Spirometry, pulse oximetry, full lung CT scan +/- CTA (65 minutes) Exam components (1000) or Full lung CT scan (1000) Spirometry, pulse oximetry, 250 uL blood, creatinine Dual source CTA for pulmonary perfusion
Exam 6 Ancillary Studies Obesity-related epigenetic changes and type-2 diabetes N=2800 participants with isolated monocytes from MESA Epigenomics ancillary study 15 minutes Blood and urine for eGFR, fasting glucose, lipids profiles, and albuminuria assessment. Liu, Yongmei #Participants Time Burden Exam 6 components
