SWAG Network Colorectal Cancer Clinical Advisory Group Research Update - Claire Matthews

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This research update by the SWAG Network's Colorectal Cancer Clinical Advisory Group, led by Claire Matthews, covers national recruitment statistics, regional recruitment comparisons, site-specific recruitment data, and an overview of opened studies for 2022/23. The update includes insights, data cuts, and information on ongoing studies related to colorectal cancer

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SWAG Network Colorectal cancer Clinical Advisory Group Research Update - Claire Matthews 11/05/2023

National Recruitment to Colorectal Cancer Studies Apr 2021 - Mar 2022 Apr 2022 - Mar 2023 Data cut 09/05/2023 Source: ODP All Portfolio

National vs Regional Recruitment to Colorectal Cancer Studies Apr 2019 - May 23 National Recruitment SWAG Region Recruitment Data cut 09/05/2023 Source: ODP All Portfolio

Recruitment by Site to Colorectal Cancer Studies 2022/2023 Site Name Studies linked to site Studies that have recruited Recruitment Bristol Haematology & Oncology Centre 6 6 59 Musgrove Park Hospital 10 10 53 Cheltenham General Hospital 1 1 49 Gloucestershire Royal Hospital 1 1 40 Bristol Royal Hospital for Children 1 1 22 Salisbury District Hospital 3 3 16 Royal United Hospital 3 3 15 St Michael's Hospital 2 2 8 Bristol Royal Infirmary 1 1 5 Data cut 09/05/2023 Source: ODP All Portfolio

SWAG region Colorectal Cancer Studies Opened 2022/23 (full list to be circulated) CPMS ID Short Name Sites Open Closure Sample Size Eng Eng Recruits 52280 BNT122-01 BioNTech SE Colorectal Cancer 4781/0016 Yeovil, BHOC, Musgrove 31/03/2023 01/10/2023 504 2 54218 Could supported weight loss reduce bowel cancer surgery complications? Yeovil 29/03/2023 30/06/2024 72 1 52011 MOUNTAINEER-03 BHOC 26/01/2023 29/04/2024 15 0 53642 COLO-PREVENT: A platform for developing COLOrectal cancer PREVENTion therapies Yeovil, Salisbury 02/12/2022 31/01/2028 1273 3 48817 Metastatic Colorectal Cancer Yeovil 28/09/2022 18/12/2023 6 0 52250 NERO Musgrove 11/07/2022 11/07/2023 68 42 52006 Reconstruction in Extended MArgin Cancer Surgery (REMACS) Salisbury 17/05/2022 01/03/2025 100 22 50663 ARIEL RUH 25/04/2022 30/09/2024 319 13 51104 CITRuS Stage 1; Feasibility Musgrove 22/03/2022 23/03/2024 571 107 49772 FOxTROT Platform BHOC 07/02/2022 01/08/2026 848 72 45744 Seal-G / Seal-G MIST Study (DLG-072-06 Rev5.0 18Apr2021) Salisbury 19/01/2022 30/09/2023 43 16 Full list of open studies to be circulated

West of England In Setup Colorectal Cancer Studies 2023 CPMS ID Short Name Sites Planned Opening Planned Closure Sample Size UK 55132 ACM-001-2022-2-CT-CRC (PhIIb/III S-pindolol benzoate) Yeovil, Musgrove 01/01/2024 01/09/2025 40 55040 Studying drug action in pleural effusion and ascites: a pilot study Salisbury 31/05/2023 15/12/2024 360 53968 Dostarlimab Neoadjuvant Rectal Study BHOC 22/05/2023 22/04/2024 10 52581 STELLAR-303 BHOC 19/12/2022 15/04/2024 21 51892 Correct MRD I BHOC, Salisbury 18/06/2023 30/12/2023 78 51497 61186372CRC2001 (Ph Ib/II Amivantemab) BHOC 01/06/2023 02/10/2023 7 44460 Ondansetron for Low Anterior Resection Syndrome (OARS) Salisbury 01/01/2023 31/05/2024 134 41403 PRESERVE Salisbury, Southmead 01/01/2021 31/01/2021 146 Data cut 09/05/2023 Source: ODP All Portfolio

Cancer Patient Experience Survey 2021 Results - Research Question Somerset, Wiltshire, Avon and Gloucestershire: Published July 2022. The score shows the percentage of respondents who gave the most favourable response to a question The expected range charts in this report show a bar with the lowest and highest score received for each question nationally. Within this bar, an expected range is given (in grey) and a black diamond represents the actual score for this Alliance.

Cancer Patient Experience Survey 2021 Results - Research Question SWAG region had a below average score compared to the national result for discussions about research during their appointments Patient representatives have voiced a desire to have research mentioned at their appointments even if there is none available to them at that time. How can you increase conversations about research in your tumour site?

Associate PI Scheme https://www.nihr.ac.uk/health-and-care-professionals/career-development/associate-principal-investigator- scheme.htm A six month in-work training opportunity, providing practical experience for healthcare professionals starting their research career. People who would not normally have the opportunity to take part in clinical research in their day to day role have the chance to experience what it means to work on and deliver a NIHR portfolio trial under the mentorship of an enthusiastic Local PI. CIs working with a CTU can register their study on the scheme https://www.nihr.ac.uk/health-and-care-professionals/career-development/register-your-study-for-the- associate-principal-investigator-scheme.htm

API Scheme Colorectal Cancer Studies open in SWAG Region CPMS ID Study Short Name Sites 18067 Add-Aspirin BHOC, Salisbury, Cheltenham, Musgrove, Southmead, Yeovil, Weston 20443 TRACC UHBW 31184 PLATO UHBW, GHFT 49772 FoxTrot RUH, UHBW 50663 ARIEL GHFT, RUH 42483 COLO-COHORT GHFT

NIHR ODP https://odp.nihr.ac.uk/ Open data platform. Data on performance and restart across whole CRN, including all specialty areas NIHR Be Part of Research https://www.ukctg.nihr.ac.uk/ See which studies are open across the country National Cancer Research Institute Portfolio Maps http://csg.ncri.org.uk/portfolio/portfolio-maps/ View current national portfolio of open, closed and in set up cancer studies Find a Clinical Research Study (ODP) http://csg.ncri.org.uk/portfolio/portfolio-maps/ Search for a study to fit criteria. Good for horizon scanning, eligibility criteria