Tumor Heterogeneity and Chemotherapy Resistance
Tumor heterogeneity refers to the presence of different cell types within a tumor, each with unique mutations. This diversity impacts the tumor's response to chemotherapy, as some cells may be sensitive while others are resistant. This simulation explores how varying mutations affect treatment outcomes.
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Presentation Transcript
Tumor Heterogeneity and Chemotherapy Resistance: The Fault in Our Cells Koch Institute for Integrative Cancer Research MIT
Do you think all of the cancer cells in a tumor have the same mutations?
Chemotherapy Resistance Different tumor cells will respond to chemotherapy in different ways Sensitive to therapy Resistant to therapy
Chemotherapy Resistance Different tumor cells will respond to chemotherapy in different ways Tumors have cells with many different mutations How does this affect the tumor s response to therapy?
Simulation Rules 1. Put 10 of each color bead in your bag. This is your tumor. This is your tumor. 2. In each of 5 cups, put: Pink Pink Orange Orange Yellow Yellow Purple Purple Green Green 1 bead 1 bead 2 beads 2 beads 3 beads 5 X This represents division of the cancer cells This represents division of the cancer cells
Simulation Rules Person 1 = Chemotherapy Chemotherapy: kill cells by taking them out of the bag one-by-one Person 2 = Cancer cell division Cancer cell division: Every 30 seconds, add one cup of cells Person 3 = Chemo resistance Chemo resistance: When 3 of your resistant cells have been killed, put 2 back in the bag Look Look at your instructions to see which cells are at your instructions to see which cells are resistant for your group resistant for your group
Simulation Results 30 Pink Orange Yellow Purple Green 22.5 15 7.5 0
