Characteristics and Impact of Pruritus in Psoriasis: A Comprehensive Analysis
"Explore the characteristics and impact of pruritus in psoriasis through a cross-sectional study involving 634 patients from Germany, Poland, and Russia. Findings reveal high prevalence of pruritus, its association with significant burden on patients, and the need for effective management strategies to address this symptom effectively."
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INFODERMATOLOGY SUMMARIES Focus sulla psoriasi Un servizio di aggiornamento scientifico sostenuto da un contributo educazionale non condizionante di
Dermatology summaries collection Dalla lettura internazionale | Focus sulla psoriasi A comprehensive, tri-national, cross-sectional analysis of characteristics and impact of pruritus in psoriasis Hawro M, Sahin E, Ste M, et al. J Eur Acad Dermatol Venereol. 2022 Nov;36(11):2064-2075 Background & methods Results Conclusions Messaggi chiave 2 Un servizio di aggiornamento scientifico sostenuto da un contributo educazionale non condizionante di 2
Focus sulla psoriasi Messaggi chiave Il presente studio trasversale ha incluso 634 pazienti e 246 controlli sani per valutare le caratteristiche e l impatto del prurito in una coorte di pazienti con psoriasi provenienti da Germania, Polonia e Russia. Il prurito ha un alta prevalenza nella psoriasi e si associa a un forte impatto sul paziente; le terapie attuali sono spesso insufficienti per controllare tale sintomo. Una corretta gestione della malattia dovrebbe includere la valutazione e il controllo del prurito e dovrebbero essere sviluppate terapie efficaci. 3 Developed by 3
Focus sulla psoriasi Background & objectives Background Pruritus is prevalent in psoriasis but still many features of pruritus, its response to therapy and its burden in psoriasis remain to be better characterized. Objective To investigate characteristics and burden of pruritus in an international cohort of patients with psoriasis. 4 Developed by 4
Focus sulla psoriasi Methods This cross-sectional study included a total of 634 patients and 246 controls from Germany, Poland and Russia. Physicians examined and interviewed participants, recording clinical characteristics, such as severity, therapy and localization of psoriatic lesions. Participants filled out self-reported questionnaires including questions on pruritus severity and impact, characteristics, and response to therapy, and quality of life (QoL). Localization patterns of pruritus and skin lesions were visualized using body heat maps. 5 Developed by 5
Focus sulla psoriasi Results Most patients (82%) experienced pruritus throughout their disease, and 75% had current pruritus. The majority of patients (64%) perceived pure pruritus, and those who reported additional painful and/or burning sensations (36%) reported overall stronger pruritus. The scalp was the most frequently reported localization of pruritus, even in the absence of skin lesions. Body surface area (BSA) of pruritus was not linked to pruritus intensity, but to BSA of psoriatic lesions (rho = 0.278; p <0.001). One third of patients (31%) reported impaired sex-life, and 4% had suicidal ideations due to pruritus. In up to one third of patients, psoriasis therapies had little or no effect on pruritus. The only therapeutic option offered to some of these patients were antihistamines, which appeared to be effective in most cases. 6 Developed by 6
Focus sulla psoriasi Conclusion and perspectives Pruritus is highly prevalent in psoriasis and is linked to a significant burden. Current psoriasis therapies are frequently insufficient to control pruritus. Managing psoriasis should include the assessment and control of itch. Efficient antipruritic therapies should be developed and be made available for patients with psoriasis. 7 Developed by 7
INFODERMATOLOGY SUMMARIES Focus sulla psoriasi Un servizio di aggiornamento scientifico sostenuto da un contributo educazionale non condizionante di
