Factors Affecting Erythropoiesis and Hemoglobin Synthesis
This comprehensive guide delves into the factors influencing erythropoiesis and hemoglobin synthesis, including nutritional, hormonal, and growth factors. Explore the intricate process of hemopoietic growth and the synthesis of essential components like heme. Uncover the role of organs like the liver and bone marrow in regulating erythropoiesis, offering a deeper understanding of hematopoiesis.
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Presentation Transcript
Factors affecting Erythropoiesis and Hb synthesis Dr Sunita Mittal
Learning Objectives Factors affecting erythropoiesis Hemoglobin synthesis
Factors regulating Erythropoiesis Growth or Developmental Factors Nutritional Factors Hormonal Factors Healthy Liver and Bone marrow
Hemopoietic Growth Factors-EPO (Erythropoietin) A glycoprotein hormone (mw 34000 d) and a cytokine (protein signaling molecule) for erythrocyte precursors in the bone marrow. 90% from the kidney 10% form the liver
Nutritional Factors regulating Erythropoiesis A) Proteins: B) Minerals: Iron (Fe++) 2. Copper (Cu++) 3. Cobalt (Co)
Nutritional Factors regulating Erythropoiesis C) Vitamins:
Hormonal Factors regulating Erythropoiesis Thyroid Cortisol Androgens
Regulation of Erythropoiesis - Liver and Bone marrow Liver Bone marrow
Hemoglobin The hemoglobin is pigmented globular protein structure
Hemoglobin Structure Consists of 4 Subunits- Heme group Globin chain Function
Hemoglobin Synthesis Heme synthesis starts in Mitochondria of normoblast with the condensation of Glycine and Succinyl Coenzyme A
Self Assessment Which is not true for free Hb in blood- a) it increase the blood viscosity b) increase the osmotic/oncotic pressure c) it can be lost by kidneys in urine d) it damages the liver Normal reticulocyte count at birth is- a)1-2% b)<1% c)5-10% d)2-6% Erythropoietin is secreted from- a)Kidney b)Liver c)tissue macrophage d)spleen life span of foetal RBC - a)120 days b)120 weeks c) 80 days d) 80 weeks
