Types of Vasculitis Leading to Aortitis
Various types of vasculitis can lead to aortitis, affecting vessels of different sizes. Large vessel vasculitides target well-developed vessel layers, while variable vessel vasculitis like Behcet's and Cogan's syndrome can impact vessels of any size. Rarely, ANCA-vasculitis can also cause aortitis. In non-primary vasculitis processes, conditions such as IgG4-related systemic disease, relapsing polychondritis, systemic lupus erythematosus, and systemic infections can lead to aortitis.
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Presentation Transcript
Which types of vasculitis lead to aortitis? Emily Grodinsky 11.5.2020
More on primary vasculitidities Even diseases like GCA/Takayasu arteritis have significant effects from the smaller vessels (e.g., ophthalmic or retinal arteries in GCA leading to significant morbidity, despite not being large vessels ) Large vessel vasculidities have a predilection for well-developed wall layers like the elastic layer, found in large/medium arteries Variable vessel vasculitis: - Behcets - Cogan s syndrome (ocular inflammation, inner ear disease) Ultimately, vessels of any size can be affected in any vasculitic process
ANCA-vasculitis aortitis -- rare but has been reported
Aortitis in non-primary vasculitis processes IgG4-related systemic disease (aortitis suspected to occur in 10-30% of patients w/ this disease) Relapsing polychondritis Systemic Lupus Erythematosus Systemic infections (e.g., syphilis, tuberculosis)
