Crossed Aldol Reaction in Carbonyl Condensation
Crossed aldol reactions in carbonyl condensation involve the formation of highly conjugated products by removing acidic hydrogens from one carbonyl component. The dicarbonyl compound becomes the enolate, leading to a series of steps as shown in Figure 24.2 between diethylmalonate and benzaldehyde.
Download Presentation
Please find below an Image/Link to download the presentation.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.
You are allowed to download the files provided on this website for personal or commercial use, subject to the condition that they are used lawfully. All files are the property of their respective owners.
The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author.
E N D
Presentation Transcript
Carbonyl Condensation Reactions Crossed Aldol Reactions [2] When one carbonyl component has especially acidic hydrogens, these hydrogens are more readily removed than the other H atoms. As a result, the - dicarbonyl compound always becomes the enolate component of the aldol reaction. 4
Carbonyl Condensation Reactions Crossed Aldol Reactions Figure 24.2 below shows the steps for the crossed aldol reaction between diethylmalonate and benzaldehyde. In this type of crossed aldol reaction, the initial -hydroxy compound always loses water to form the highly conjugated product. Figure 24.2 Crossed aldol reaction between benzaldehyde and CH2(COOEt)2 5
